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Willows Scientific Papers for the following veterinary specialists:
Hamilton-Bennett SE, Oxley B, Behr S (2017) Accuracy of a patient-specific 3D printed drill guide for placement of cervical transpedicular screws. Veterinary Surgery. 2017 Oct 24. [Epub ahead of print] PubMed PMID: 29064584.
Mari L, Behr S, Shea A, Dominguez E, Johnson PJ, Ekiri A, De Risio L (2017) . Outcome comparison in dogs with a presumptive diagnosis of thoracolumbar fibrocartilaginous embolic myelopathy and acute non-compressive nucleus pulposus extrusion. Veterinary Record. 2017 Sep 16;181(11):293.
Sinead E Bennett and Sebastien Behr (2016) Retrograde migration and subcutaneous coiling of the peritoneal catheter of a ventriculoperitoneal shunt in a cat. Journal of Feline Medicine and Surgery Open Reports 1–7.
Oxley, B., Behr, S (2016) Stabilisation of a cranial cervical vertebral fracture using a 3D printed patient-specific drill guide. Journal of Small Animal Practice 57 (5) 277.
Bersan E, McConnell F, Trevail R, Behr S, De Decker S, Volk HA, Smith PM, Gonçalves R. (2015) Cervical intervertebral foraminal disc extrusion in dogs: clinical presentation, MRI characteristics and outcome after medical management. Vet Rec. 6;176(23):597. doi: 10.1136/vr.102851. Epub 2015 Mar 5. PubMed PMID: 25745084.
Elford J, Monteiro R, McKee M, Behr S. (2012) Possible case of blue-green algae (Cyanobacteria) toxicity. Veterinary Record 24;171(21):541-2. dos: 10.1136/vr.e7879. PubMed PMID: 23180715.
Marioni-Henry K, Monteiro R, Behr S. (2012) Complex partial orofacial seizures in English cats. Veterinary Record 170, 471.
Roynard P, Behr S, Barone G, Llabrés-Diaz F, Cherubini GB. (2012) Idiopathic hypertrophic pachymeningitis in six dogs: MRI, CSF and histological findings, treatment and outcome. Journal of Small Animal Practice 53, 543-548
Idiopathic hypertrophic pachymeningitis has been described in humans as a rare, chronic progressive non-specific inflammatory and fibrotic disease of the dura mater. This is a case series of six canine cases of presumptive or confirmed intracranial idiopathic hypertrophic pachymeningitis. These dogs were included in this retrospective study, based on magnetic resonance imaging findings. All presented with pachymeningeal thickening and enhancement without involvement of the leptomeninges on magnetic resonance imaging and no underlying cause identified on cerebrospinal fluid analysis, complete blood count, serum biochemistry and infectious disease titres. Histopathological examination was available in one case. Response to immunomodulatory treatment (corticosteroids and cytosine arabinoside) was achieved in five cases. Idiopathic hypertrophic pachymeningitis should be considered as a possible differential diagnosis for dogs with pachymeningeal thickening on magnetic resonance imaging and no identified underlying cause. The prognosis appears to be fair to poor.
© 2012 British Small Animal Veterinary Association.
Terzo E, McConnell JF, Shiel RE, McAllister H, Behr S, Priestnall SL, Smith KC, Nolan CM, Callanan JJ. (2012) Unique topographic distribution of greyhound nonsuppurative meningoencephalitis. Veterinary Radiology and Ultrasound 29 [Epub ahead of print]
Greyhound nonsuppurative meningoencephalitis is an idiopathic breed-associated fatal meningoencephalitis with lesions usually occurring within the rostral cerebrum. This disorder can only be confirmed by postmortem examination, with a diagnosis based upon the unique topography of inflammatory lesions. Our purpose was to describe the magnetic resonance (MR) imaging features of this disease. Four Greyhounds with confirmed Greyhound nonsuppurative meningoencephalitis were evaluated by MR imaging. Lesions predominantly affected the olfactory lobes and bulbs, frontal, and frontotemporal cortical gray matter, and caudate nuclei bilaterally. Fluid attenuation inversion recovery (FLAIR) and T2 weighted spin-echo (T2W) sequences were most useful to assess the nature, severity, extension, and topographic pattern of lesions. Lesions were predominantly T2-hyperintense and T1-isointense with minimal or absent contrast enhancement.
© 2012 Veterinary Radiology & Ultrasound.
McKee M, Behr S, Monteiro R. (2011) Spinal pain and presumptive diagnosis of meningitis in young dogs. Vet Record 169, 54
Davies E. S. S., Volk H. A., Behr S., Summers B., de Lahunta A., Syme H., Jull P. et al. (2011). Porencephaly and hydranencephaly in six dogs. Veterinary Record (on line)
A retrospective study was performed to identify dogs with cerebrospinal fluid-filled cavitatory lesions on MRI. Six dogs were included and the lesions were classified. In the three dogs in the present study with hydranencephaly, unilateral but complete loss of the temporal and parietal lobes was noted and had almost complete loss of the occipital and frontal lobes of a cerebral hemisphere. In the three dogs with porencephaly, there was unilateral incomplete loss of the parietal lobe and one dog had additional partial loss of the temporal and frontal lobes. Two of the dogs with porencephaly had seizures; the third showed no associated clinical signs. The dogs with hydranencephaly had mentation changes and circled compulsively. The two porencephalic dogs with seizures were treated with phenobarbitone. One of the dogs with hydranencephaly showed increased frequency and duration of circling; one dog's clinical signs did not progress and the third dog was euthanased due to increasing aggression. The dog with increased circling had ventriculoperitoneal shunt placement and the circling frequency reduced.
Source: Willows Veterinary Centre, Highlands Road, Shirley, Solihull, West Midlands B90 4NH, UK.
Vanhaesebrouck AE, Shelton GD, Garosi L, Harcourt-Brown TR, Couturier J, Behr S, Harvey RJ, Jeffery ND, Matiasek K, Blakemore WF, Granger N. (2011) A Novel Movement Disorder in Related Male Labrador Retrievers Characterized by Extreme Generalized Muscular Stiffness. J Vet Intern Med. doi: 10.1111/j.1939-1676.2011.0757.x. [Epub ahead of print] PubMed PMID: 21781161
A Novel Movement Disorder in Related Male Labrador Retrievers Characterized by Extreme Generalized Muscular Stiffness.
Vanhaesebrouck AE, Shelton GD, Garosi L, Harcourt-Brown TR, Couturier J, Behr S, Harvey RJ, Jeffery ND, Matiasek K, Blakemore WF, Granger N.
Department of Veterinary Medicine, The Queen's Veterinary School Hospital, University of Cambridge, Cambridge, UK
Comparative Neuromuscular Laboratory, Department of Pathology, School of Medicine, University of California, San Diego, CA Davies Veterinary Specialists, Higham Gobion, UK Department of Pharmacology, The School of Pharmacy, London, UK Section of Clinical & Comparative Neuropathology, Institute of Veterinary Pathology, Ludwig Maximilians University of Munich, Munich, Germany Willows Referral Service, Solihull, UK Lloyd Veterinary Medical Center, College of Veterinary Medicine, Iowa State University, Ames, OH. Objectives: To describe the clinical phenotype of a new motor disorder in Labrador Retrievers. Animals and Methods: Case series study. Seven young male Labrador Retrievers presented for evaluation of stiff gait. Results: All affected dogs had generalized muscular stiffness, persistent at rest and resulting in restricted joint movements. They showed a forward flexed posture, festinating gait, and bradykinesia. Signs developed between 2 and 16 months of age and tended to stabilize in adulthood. Needle electromyogram in the conscious state showed continuous motor unit activity in resting epaxial and proximal limb muscles. This activity was abolished by general anesthesia. Muscle and nerve histopathology was normal. In 2 dogs necropsied, astrocytosis was evident throughout the spinal cord gray matter, reticular formation and caudate nuclei. Decreased neuronal counts were selectively found in the spinal cord Rexed's lamina VII, but not in VIII and IX. Pedigree analysis showed that the affected dogs were from 5 related litters. Conclusions and Clinical Importance: This new hypertonicity syndrome in Labrador Retrievers is unique because of the selective distribution of the histological lesions, the lack of progression in adulthood, and its exclusive occurrence in male dogs. Pedigree analysis suggests an X-linked hereditary disease, although other modes of inheritance cannot be ruled out with certainty. We hypothesize that altered output from basal nuclei and reticular formation together with motor neuron disinhibition caused by a decreased number of spinal cord interneurons leads to the muscular stiffness.
PMID: 21781161 [PubMed - as supplied by publisher]
Behr S. (2010) Binding truth and time. J Small Anim Pract. 51, 135-6. PubMed PMID: 20406357.
Behr S, Llabrés-Días FJ, Radaelli ST. (2009) Treatment of meningoencephalitis of unknown origin in a dog. Vet Rec. 164, 627-9. PubMed PMID: 19448257.
Menaut P, Landart J, Behr S, Lanore D, Trumel C. (2008) Treatment of 11 dogs with meningoencephalomyelitis of unknown origin with a combination of prednisolone and cytosine arabinoside. Vet Rec. 162, 241-5. PubMed PMID: 18296666.
Treatment of 11 dogs with meningoencephalomyelitis of unknown origin with a combination of prednisolone and cytosine arabinoside.
Menaut P, Landart J, Behr S, Lanore D, Trumel C.
Service de Pathologie Médicale des Carnivores Domestiques, Ecole Nationale Vétérinaire de Toulouse, 31076 Toulouse Cedex, France.
The records of 11 dogs with evidence of meningoencephalomyelitis of unknown origin were reviewed. Two of them had had a focal form of the disease and the other nine a disseminated form. The forebrain was involved in five of the nine dogs with disseminated disease, the brainstem in all nine and the cerebellum in one. They had been treated with courses of cytosine arabinoside every three weeks and immunosuppressive doses of prednisolone. Their response to the treatment, in terms of quality of life, was judged by their owners and referring veterinarians to have been excellent in five, good in five and poor in one; their survival times ranged from 78 days to more than 603 days. The cumulative probability of survival at two years was 58.4 per cent. No signs of myelosuppression or other side effects associated with cytosine arabinoside were observed.
PMID: 18296666 [PubMed - indexed for MEDLINE]
Behr S, Cauzinille L. (2006) Aseptic suppurative meningitis in juvenile boxer dogs: retrospective study of 12 cases. J Am Anim Hosp Assoc; 42, 277-82. PubMed PMID: 16822766.
Behr S, Cauzinille L.
Department of Neurology, Fregis Referral Hospital, Arcueil, France.
Immune-mediated central nervous system inflammation is described in a series of 12 juvenile boxer dogs. A diagnosis of steroid-responsive meningitis-arteritis was made based on the clinical presentation and on diagnostic findings. The boxer breed was at a higher risk for this inflammatory condition than other breeds. Long-term follow-up (>2 years) confirmed a better prognosis in this breed than in the beagle and the Bernese mountain dog. Complete resolution of clinical signs without significant deficits or recurrences was obtained in all cases. Early clinical recognition and immunosuppressive treatment resulted in a better response and complete resolution of the disorder.
PMID: 16822766 [PubMed - indexed for MEDLINE]
Behr S, Trumel C, Cauzinille L, Palenché F, Braun JP. (2006) High resolution protein electrophoresis of 100 paired canine cerebrospinal fluid and serum. J Vet Intern Med. 20, 657-62. PubMed PMID: 16734104.
High resolution protein electrophoresis of 100 paired canine cerebrospinal fluid and serum.
Behr S, Trumel C, Cauzinille L, Palenché F, Braun JP.
Frégis Veterinary Clinique, Arcueil, France.
This study was performed to investigate the diagnostic relevance of cerebrospinal fluid (CSF) high resolution electrophoresis. The laboratory technique was applied to 100 paired samples of canine CSF and serum, with paired samples tested during the same analytical run, as recommended in human medicine. Ninety four of the dogs had a neurological disease and 6 healthy dogs served as a control group. A strong linear correlation between CSF total protein concentration and the albumin quota (AQ) was found in the control group and in the inflammatory (infectious or noninfectious), neoplastic, and miscellaneous groups: AQ = 0.015 CSF total protein--0.102, r = 0.990. This correlation suggests that an increased CSF total protein concentration can be an indicator of blood brain barrier dysfunction. The highest median AQ value was found in the aseptic suppurative meningitis group, but no statistical differences were found between this and the other groups. The AQ, calculated with this technique, did not provide any additional information. Moreover, although unexpected, the electrophoretic profiles were not characteristic of any particular disease. In conclusion, this study did not confirm high resolution electrophoresis of paired CSF and serum samples to be a valuable ancillary diagnostic tool for canine neurological diseases.
PMID: 16734104 [PubMed - indexed for MEDLINE]
Behr S, Trumel C, Palanché F, Braun JP. (2003) Assessment of a pyrogallol red technique for total protein measurement in the cerebrospinal fluid of dogs. J Small Anim Pract. 44, 530-3. PubMed PMID: 14692549.
Assessment of a pyrogallol red technique for total protein measurement in the cerebrospinal fluid of dogs.
Behr S, Trumel C, Palanché F, Braun JP.
Département des Sciences Biologiques et Fonctionnelles & UMR Physiopathologie et Toxicologie Expérimentales, Ecole Nationale Vétérinaire, 23 chemin des Capelles, 31076 Toulouse Cedex, France.
The measurement of protein concentration in the cerebrospinal fluid is a basic analytical method in neurology. In this study, a pyrogallol red technique using a human albumin calibrator previously validated in human medicine was tested for canine samples, and the results were compared with those obtained using urine test strips. Pyrogallol red significantly (P
PMID: 14692549 [PubMed - indexed for MEDLINE]
Behr S, Trumel C, Braun J-P (2002) Analysis of proteins in the cerebrospinal fluid of dogs: a review. Prat Med Chir Anim Comp 38, 101-113
Books and Book Chapters
S. Behr and S. Radaelli - Chapter 12: Neurological lameness. BSAVA Manual of Musculoskeletal disease 2nd Edition (in press)
Llabrés-Díaz F.J. and Behr S. (2010) "3D acquisitions in small animal MRI – a case report". EAVDI yearbook 2010 121-131.
Behr S and Green R. (2012) "Post-operative supportive care and physical rehabilitation", in Small Animal Neurological Emergencies, S.R. Platt and L. Garosi, Manson Publishing
Behr S, Trumel C, Braun J-P. (2002) "Cerebrospinal fluid proteins analysis in dogs : a review”. Prat Med Chir Anim Comp, 37, 91-102.
Murtagh K, Arrol L, Goncalves R, Granger N, German AJ, Smith PM. (2015) Hypothalamic-anterior pituitary hormone deficiencies following traumatic brain injury in dogs.Vet Rec. 3;176(1):20
Traumatic brain injury is an important cause of hypopituitarism in human beings, but limited information exists in the veterinary literature regarding this condition. The primary study objective was to investigate whether hypothalamic-anterior pituitary axis dysfunction exists following traumatic brain injury in 17 client owned dogs. In this retrospective, observational, open, cohort study, information about dogs presented to four separate referral centres between April 2008 and October 2013 was reviewed. Cases were included if they had suffered from non-fatal traumatic brain injury, resulting in neurological dysfunction, and follow-up evaluation included measurement of the serum concentration of insulin-like growth factor 1 (IGF-1), endogenous adrenocorticotrophic hormone (ACTH), basal cortisol, thyroid-stimulating hormone, total thyroxine (TT4) and, if appropriate, free thyroxine. Decreased IGF-1 concentration was the most common abnormality detected (7/17, 41 per cent; median 132 ng/ml, range
Arrol LP, Kerrins AM, Yamakawa Y, Smith PM. J Feline (2011) Fucosidosis in a domestic shorthair cat. Med Surg. 13(2):120-4
This paper documents the first reported case of fucosidosis in a cat. The cat presented with signs of forebrain and cerebellar dysfunction and a magnetic resonance imaging scan of the brain suggested a degenerative or metabolic disease process. A fine needle aspirate of grossly normal lymph nodes revealed vacuolated lymphocytes and a renal biopsy of an irregular shaped kidney identified vacuolated tubular epithelial cells. A white cell lysosomal enzyme screen revealed negligible α-fucosidase activity. Fucosidosis should be considered in the differential diagnosis of young cats with cerebellar dysfunction and must be added to the list of lysosomal storage diseases affecting the cat.
Arrol L, Penderis J, Garosi L, Cripps P, Gutierrez-Quintana R, Gonçalves R. (2012) Aetiology and long-term outcome of juvenile epilepsy in 136 dogs. Vet Rec. 170(13):335
The aetiology and outcome of dogs with juvenile-onset seizures were investigated. One hundred and thirty-six dogs whose first seizure occurred before the age of one year were investigated. One hundred and two dogs were diagnosed with idiopathic epilepsy (IE), 23 with symptomatic epilepsy (SE), nine with reactive seizures (RS) and two with probable symptomatic epilepsy (pSE). The outcome was known in 114 dogs; 37 per cent died or were euthanased as a consequence of seizures. The mean survival time of this population of dogs was 7.1 years. Factors that were significantly associated with survival outcome included the diagnosis of SE and the number of antiepileptic drugs (AEDs) used before investigation. The use of one AED before investigation and a diagnosis of SE were associated with a negative outcome, whereas receiving no AED medications before referral was associated with a longer survival. For dogs with IE, survival time was shortened if the dog was a border collie or with a history of status epilepticus;receiving no AEDs before referral in the IE group was associated with a positive outcome. Seizure-free status was achieved in 22 per cent of dogs diagnosed with IE. While the survival times were longer than previously reported in canine epilepsy, similar remission rates to those reported in childhood epilepsy, where a 70 per cent remission rate is documented, were not seen in the canine juvenile population.
Arrol, L. and Smith, P.M (2010) Exercise induced nystagmus in a dog. In: 23rd Annual Symposium of the ECVN, UK.
Elford J, Monteiro R, McKee M, Behr S (2012) Possible case of blue-green algae (Cyanobacteria) toxicity. Veterinary Record, 24;171(21):541-2. dos: 10.1136/vr.e7879. PubMed PMID: 23180715.
Ricco C, Bouvy B, Gomes E, Cauzinille L. (2015) Lumbar vertebral angiomatosis in a cat: A clinical case. Revue Méd. Vét., Jan, 166 (11-12), 332-335.
Ricco C, Cauzinille L. Particularities of cauda equina syndrome in the cat (in french) (2014) Le nouveau practicien Vétérinaire, Oct, 2014, 58 (13), 49-53.
Oliveira M, Mcconnell JF, Maddox TW, Sanchez-Masian D, Gonçalves R. (2018) Agreement between transverse T2-weighted and three-dimensional constructive interference in steady state sequences in the evaluation of spinal cord disease in dogs. Vet Rec. 182(26):745
Oliveira M, Fernández F, Solé J, Pumarola M. (2018) Morphological, histological and immunohistochemical study of the area postrema in the dog. Anat Sci Int. 93(2):188-196
Posporis C, Grau-Roma L, Travetti O, Oliveira M, Polledo L, Wessmann A. (2017) Meningeal carcinomatosis and spinal cord infiltration caused by a locally invasive pulmonary adenocarcinoma in a cat. JFMS Open report 3(2):
Polledo L, Oliveira M, Adamany J, Graham P, Baiker K. (2017) Hypophysitis, Panhypopituitarism, and Hypothalamitis in a Scottish Terrier Dog. J Vet Intern Med. 31(5):1527-1532
Oliveira M, De La Fuente C, Pumarola M, Añor S. (2014) Imaging diagnosis: Cranial cervical intraspinal schwannoma in a dog. Vet Radiol Ultrasound 55(3):300-4